Which Process of Genetic Recombination Involves Genes From Both Parents

Which Process of Genetic Recombination Involves Genes From Both Parents

Production of offspring with combinations of traits that differ from those found in either parent

A current model of meiotic recombination, initiated by a double-strand break or gap, followed by pairing with an homologous chromosome and strand invasion to initiate the recombinational repair process. Repair of the gap can pb to crossover (CO) or non-crossover (NCO) of the flanking regions. CO recombination is thought to occur past the Double Holliday Junction (DHJ) model, illustrated on the right, above. NCO recombinants are thought to occur primarily past the Synthesis Dependent Strand Annealing (SDSA) model, illustrated on the left, to a higher place. Most recombination events announced to be the SDSA type.

Genetic recombination
(besides known as
genetic reshuffling) is the exchange of genetic material between different organisms which leads to production of offspring with combinations of traits that differ from those institute in either parent. In eukaryotes, genetic recombination during meiosis can lead to a novel fix of genetic information that can exist further passed on from parents to offspring. Most recombination occurs naturally and tin can exist classified into two types: (one)
interchromosomal
recombination, occurring through contained assortment of alleles whose loci are on different merely homologous chromosomes (random orientation of pairs of homologous chromosomes in meiosis I); & (2) intrachromosomal
recombination, occurring through crossing over.[one]

During meiosis in eukaryotes, genetic recombination involves the pairing of homologous chromosomes. This may be followed past data transfer between the chromosomes. The information transfer may occur without physical substitution (a section of genetic material is copied from one chromosome to another, without the donating chromosome existence inverse) (come across SDSA pathway in Effigy); or by the breaking and rejoining of Dna strands, which forms new molecules of DNA (see DHJ pathway in Figure).

Recombination may too occur during mitosis in eukaryotes where it usually involves the two sister chromosomes formed afterward chromosomal replication. In this case, new combinations of alleles are not produced since the sister chromosomes are unremarkably identical. In meiosis and mitosis, recombination occurs between similar molecules of DNA (homologous sequences). In meiosis, non-sis homologous chromosomes pair with each other and so that recombination characteristically occurs between not-sister homologues. In both meiotic and mitotic cells, recombination between homologous chromosomes is a common mechanism used in Deoxyribonucleic acid repair.

Gene conversion – the process during which homologous sequences are made identical besides falls under genetic recombination.

Genetic recombination and recombinational DNA repair besides occurs in bacteria and archaea, which utilize asexual reproduction.

Recombination can exist artificially induced in laboratory (in vitro) settings, producing recombinant Dna for purposes including vaccine development.

V(D)J recombination in organisms with an adaptive allowed system is a blazon of site-specific genetic recombination that helps immune cells chop-chop diversify to recognize and adapt to new pathogens.

Synapsis

[edit]

During meiosis, synapsis (the pairing of homologous chromosomes) ordinarily precedes genetic recombination.

Mechanism

[edit]

Genetic recombination is catalyzed by many dissimilar enzymes. Recombinases are cardinal enzymes that catalyse the strand transfer step during recombination. RecA, the chief recombinase institute in
Escherichia coli, is responsible for the repair of Dna double strand breaks (DSBs). In yeast and other eukaryotic organisms there are two recombinases required for repairing DSBs. The RAD51 protein is required for mitotic and meiotic recombination, whereas the DNA repair protein, DMC1, is specific to meiotic recombination. In the archaea, the ortholog of the bacterial RecA protein is RadA.

Bacterial recombination

In Leaner there are:

  • regular bacterial recombination, likewise every bit noneffective transfer of genetic cloth, expressed as
  • unsuccessful transfer or abortive transfer which is whatever bacterial DNA transfer of the donor cell to recipients who have set the incoming DNA as part of the genetic cloth of the recipient. Abortive transfer was registered in the following transduction and conjugation. In all cases, the transmitted fragment is diluted past the civilization growth.[2]
    [3]
    [4]

Chromosomal crossover

[edit]

In eukaryotes, recombination during meiosis is facilitated by chromosomal crossover. The crossover process leads to offspring having dissimilar combinations of genes from those of their parents, and can occasionally produce new chimeric alleles. The shuffling of genes brought about by genetic recombination produces increased genetic variation. It besides allows sexually reproducing organisms to avoid Muller’s ratchet, in which the genomes of an asexual population tend to accumulate more deleterious mutations over fourth dimension than other types of beneficial or reversing mutations.

Chromosomal crossover involves recombination between the paired chromosomes inherited from each of ane’s parents, generally occurring during meiosis. During prophase I (pachytene stage) the four available chromatids are in tight formation with one some other. While in this germination, homologous sites on ii chromatids can closely pair with ane some other, and may exchange genetic information.[5]

Because recombination tin can occur with small probability at whatsoever location along chromosome, the frequency of recombination between two locations depends on the altitude separating them. Therefore, for genes sufficiently distant on the same chromosome, the corporeality of crossover is loftier enough to destroy the correlation between alleles.

Tracking the motion of genes resulting from crossovers has proven quite useful to geneticists. Because two genes that are shut together are less likely to become separated than genes that are farther apart, geneticists can deduce roughly how far autonomously two genes are on a chromosome if they know the frequency of the crossovers. Geneticists tin also use this method to infer the presence of sure genes. Genes that typically stay together during recombination are said to be linked. One gene in a linked pair can sometimes be used as a marker to deduce the presence of another gene. This is typically used in order to discover the presence of a illness-causing factor.[6]

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The recombination frequency between two loci observed is the
crossing-over value. It is the frequency of crossing over between two linked gene loci (markers), and depends on the common distance of the genetic loci observed. For whatever fixed fix of genetic and ecology conditions, recombination in a particular region of a linkage structure (chromosome) tends to be constant, and the aforementioned is then true for the crossing-over value which is used in the production of genetic maps.[ii]
[7]

Gene conversion

[edit]

In gene conversion, a department of genetic textile is copied from one chromosome to another, without the donating chromosome beingness changed. Factor conversion occurs at high frequency at the actual site of the recombination issue during meiosis. It is a process by which a Dna sequence is copied from one DNA helix (which remains unchanged) to another DNA helix, whose sequence is altered. Factor conversion has oft been studied in fungal crosses[viii]
where the 4 products of individual meioses tin be conveniently observed. Factor conversion events can be distinguished as deviations in an private meiosis from the normal ii:2 segregation pattern (due east.g. a three:i pattern).

Nonhomologous recombination

[edit]

Recombination tin occur betwixt DNA sequences that contain no sequence homology. This can cause chromosomal translocations, sometimes leading to cancer.

In B cells

[edit]

B cells of the immune system perform genetic recombination, chosen immunoglobulin form switching. Information technology is a biological mechanism that changes an antibody from i form to another, for example, from an isotype called IgM to an isotype chosen IgG.

Genetic engineering science

[edit]

In genetic technology, recombination tin can also refer to artificial and deliberate recombination of disparate pieces of DNA, often from different organisms, creating what is called recombinant Dna. A prime example of such a use of genetic recombination is gene targeting, which can be used to add together, delete or otherwise change an organism’s genes. This technique is of import to biomedical researchers as it allows them to study the furnishings of specific genes. Techniques based on genetic recombination are also applied in protein engineering to develop new proteins of biological interest.

Recombinational repair

[edit]

Dna damages caused past a variety of exogenous agents (e.thousand. UV light, 10-rays, chemical cross-linking agents) can be repaired by homologous recombinational repair (HRR).[nine]
[10]
These findings suggest that DNA amercement arising from natural processes, such as exposure to reactive oxygen species that are byproducts of normal metabolism, are also repaired past HRR. In humans, deficiencies in the gene products necessary for HRR during meiosis probable cause infertility[11]
In humans, deficiencies in gene products necessary for HRR, such as BRCA1 and BRCA2, increase the run a risk of cancer (see DNA repair-deficiency disorder).

In bacteria, transformation is a procedure of gene transfer that ordinarily occurs between individual cells of the aforementioned bacterial species. Transformation involves integration of donor Dna into the recipient chromosome past recombination. This process appears to be an adaptation for repairing DNA damages in the recipient chromosome by HRR.[12]
Transformation may provide a benefit to pathogenic bacteria by allowing repair of DNA damage, particularly damages that occur in the inflammatory, oxidizing environment associated with infection of a host.

When 2 or more than viruses, each containing lethal genomic damages, infect the same host cell, the virus genomes can often pair with each other and undergo HRR to produce feasible progeny. This procedure, referred to as multiplicity reactivation, has been studied in lambda and T4 bacteriophages,[thirteen]
every bit well as in several pathogenic viruses. In the case of pathogenic viruses, multiplicity reactivation may be an adaptive do good to the virus since it allows the repair of DNA damages acquired past exposure to the oxidizing environment produced during host infection.[12]
See likewise reassortment.

Meiotic recombination

[edit]

Molecular models of meiotic recombination have evolved over the years as relevant evidence accumulated. A major incentive for developing a fundamental understanding of the mechanism of meiotic recombination is that such understanding is crucial for solving the trouble of the adaptive part of sex, a major unresolved issue in biology. A recent model that reflects current agreement was presented past Anderson and Sekelsky,[xiv]
and is outlined in the first figure in this article. The effigy shows that two of the iv chromatids present early in meiosis (prophase I) are paired with each other and able to interact. Recombination, in this version of the model, is initiated by a double-strand break (or gap) shown in the DNA molecule (chromatid) at the top of the first figure in this article. However, other types of DNA damage may too initiate recombination. For instance, an inter-strand cross-link (caused by exposure to a cross-linking amanuensis such as mitomycin C) can be repaired by HRR.

Every bit indicated in the outset effigy, above, ii types of recombinant product are produced. Indicated on the right side is a “crossover” (CO) type, where the flanking regions of the chromosomes are exchanged, and on the left side, a “non-crossover” (NCO) blazon where the flanking regions are not exchanged. The CO type of recombination involves the intermediate germination of two “Holliday junctions” indicated in the lower correct of the effigy by 2 X shaped structures in each of which there is an commutation of unmarried strands between the two participating chromatids. This pathway is labeled in the figure every bit the DHJ (double-Holliday junction) pathway.

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The NCO recombinants (illustrated on the left in the figure) are produced by a process referred to as “synthesis dependent strand annealing” (SDSA). Recombination events of the NCO/SDSA blazon appear to exist more mutual than the CO/DHJ type.[15]
The NCO/SDSA pathway contributes little to genetic variation, since the artillery of the chromosomes flanking the recombination event remain in the parental configuration. Thus, explanations for the adaptive function of meiosis that focus exclusively on crossing-over are inadequate to explain the majority of recombination events.

Achiasmy and heterochiasmy

[edit]

Achiasmy
is the miracle where autosomal recombination is completely absent in one sex of a species. Achiasmatic chromosomal segregation is well documented in male person
Drosophila melanogaster.
Heterochiasmy
occurs when recombination rates differ between the sexes of a species.[16]
This sexual dimorphic design in recombination rate has been observed in many species. In mammals, females most often have higher rates of recombination. The
“Haldane-Huxley rule”
states that achiasmy usually occurs in the heterogametic sex.[16]

RNA virus recombination

[edit]

Numerous RNA viruses are capable of genetic recombination when at to the lowest degree two viral genomes are present in the aforementioned host cell.[17]
[xviii]
Recombination is largely responsible for RNA virus diversity and immune evasion.[xix]
RNA recombination appears to be a major driving force in determining genome compages and the form of viral evolution amidst picornaviridae ((+)ssRNA) (e.1000. poliovirus).[20]
In the retroviridae ((+)ssRNA)(e.thousand. HIV), damage in the RNA genome appears to be avoided during reverse transcription by strand switching, a grade of recombination.[21]
[22]

Recombination also occurs in the reoviridae (dsRNA)(e.g. reovirus), orthomyxoviridae ((-)ssRNA)(e.chiliad. flu virus)[22]
and coronaviridae ((+)ssRNA) (eastward.k. SARS).[23]
[24]

Recombination in RNA viruses appears to be an adaptation for coping with genome damage.[17]
Switching between template strands during genome replication, referred to as copy-pick recombination, was originally proposed to explain the positive correlation of recombination events over short distances in organisms with a DNA genome (see first Figure, SDSA pathway).[25]

Recombination tin occur infrequently between beast viruses of the same species simply of divergent lineages. The resulting recombinant viruses may sometimes cause an outbreak of infection in humans.[23]

Especially in coronaviruses, recombination may also occur even among distantly related evolutionary groups (subgenera), due to their characteristic transcription machinery, that involves subgenomic mRNAs that are formed past template switching.[26]
[24]

When replicating its (+)ssRNA genome, the poliovirus RNA-dependent RNA polymerase (RdRp) is able to carry out recombination. Recombination appears to occur by a copy choice mechanism in which the RdRp switches (+)ssRNA templates during negative strand synthesis.[27]
Recombination by RdRp strand switching also occurs in the (+)ssRNA plant carmoviruses and tombusviruses.[28]

Recombination appears to be a major driving force in determining genetic variability inside coronaviruses, also every bit the power of coronavirus species to jump from i host to some other and, infrequently, for the emergence of novel species, although the mechanism of recombination in is unclear.[23]
During the first months of the COVID-19 pandemic, such a recombination effect was suggested to accept been a critical step in the evolution of SARS-CoV-two’s power to infect humans.[29]
SARS-CoV-2’s entire receptor binding motif appeared, based on preliminary observations, to accept been introduced through recombination from coronaviruses of pangolins.[xxx]
Withal, more than comprehensive analyses later refuted this proposition and showed that SARS-CoV-2 likely evolved solely within bats and with niggling or no recombination.[31]
[32]

Part of recombination in the origin of life

[edit]

Nowak and Ohtsuki[33]
noted that the origin of life (abiogenesis) is also the origin of biological evolution. They pointed out that all known life on globe is based on biopolymers and proposed that any theory for the origin of life must involve biological polymers that act equally information carriers and catalysts. Lehman[34]
argued that recombination was an evolutionary development every bit ancient as the origins of life. Smail et al.[35]
proposed that in the primordial Earth, recombination played a fundamental role in the expansion of the initially short informational polymers (presumed to be RNA) that were the precursors to life.

See also

[edit]

  • Eukaryote hybrid genome
  • Four-gamete test
  • Homologous recombination
  • Independent assortment
  • Recombination frequency
  • Recombination hotspot
  • Site-specific recombinase technology
  • Site-specific recombination
  • Reassortment
  • V(D)J recombination

References

[edit]


  1. ^


    Daly, 1000 J; Minton, Grand Westward (October 1995). “Interchromosomal recombination in the extremely radioresistant bacterium Deinococcus radiodurans”.
    Journal of Bacteriology.
    177
    (19): 5495–5505. doi:10.1128/jb.177.19.5495-5505.1995. ISSN 0021-9193. PMC177357. PMID 7559335.


  2. ^


    a




    b




    Rieger R, Michaelis A, Green MM (1976).

    Glossary of genetics and cytogenetics: Classical and molecular
    . Heidelberg – New York: Springer-Verlag. ISBN978-three-540-07668-one.



  3. ^


    King RC, Stransfield WD (1998).

    Dictionary of genetics
    . New York, Oxford: Oxford University Press. ISBN978-0-nineteen-50944-i-one.



  4. ^


    Bajrović K, Jevrić-Čaušević A, Hadžiselimović R, eds. (2005).
    Uvod u genetičko inženjerstvo i biotehnologiju. Institut za genetičko inženjerstvo i biotehnologiju (INGEB) Sarajevo. ISBN978-9958-9344-one-4.



  5. ^


    Alberts B (2002).
    Molecular Biology of the Prison cell, Fourth Edition. New York: Garland Science. ISBN978-0-8153-3218-three.



  6. ^


    “Access Excellence”.
    Crossing-over: Genetic Recombination. The National Health Museum Resource Centre. Retrieved
    Feb 23,
    2011
    .



  7. ^


    Male monarch RC, Stransfield WD (1998).
    Dictionary of Genetics. New York, Oxford: Oxford University Printing. ISBN0-19-509442-5.



  8. ^


    Stacey KA (1994). “Recombination”. In Kendrew J, Lawrence E (eds.).
    The Encyclopedia of Molecular Biology. Oxford: Blackwell Science. pp. 945–950.



  9. ^


    Baker BS, Boyd JB, Carpenter AT, Green MM, Nguyen TD, Ripoll P, Smith PD (November 1976). “Genetic controls of meiotic recombination and somatic DNA metabolism in Drosophila melanogaster”.
    Proceedings of the National University of Sciences of the United states of America.
    73
    (xi): 4140–4. Bibcode:1976PNAS…73.4140B. doi:ten.1073/pnas.73.11.4140. PMC431359. PMID 825857.



  10. ^


    Boyd JB (1978). “Deoxyribonucleic acid repair in
    Drosophila“. In Hanawalt PC, Friedberg EC, Fox CF (eds.).
    DNA Repair Mechanisms. New York: Academic Press. pp. 449–452.



  11. ^


    Galetzka D, Weis E, Kohlschmidt N, Bitz O, Stein R, Haaf T (April 2007). “Expression of somatic Deoxyribonucleic acid repair genes in human testes”.
    Periodical of Cellular Biochemistry.
    100
    (5): 1232–nine. doi:10.1002/jcb.21113. PMID 17177185. S2CID 23743474.


  12. ^


    a




    b




    Michod RE, Bernstein H, Nedelcu AM (May 2008). “Adaptive value of sexual activity in microbial pathogens”
    (PDF).
    Infection, Genetics and Evolution.
    eight
    (3): 267–85. doi:x.1016/j.meegid.2008.01.002. PMID 18295550.



  13. ^


    Bernstein C (March 1981). “Deoxyribonucleic acid repair in bacteriophage”.
    Microbiological Reviews.
    45
    (one): 72–98. doi:10.1128/MMBR.45.one.72-98.1981. PMC281499. PMID 6261109.



  14. ^


    Andersen SL, Sekelsky J (December 2010). “Meiotic versus mitotic recombination: two dissimilar routes for double-strand break repair: the unlike functions of meiotic versus mitotic DSB repair are reflected in different pathway usage and different outcomes”.
    BioEssays.
    32
    (12): 1058–66. doi:ten.1002/bies.201000087. PMC3090628. PMID 20967781.



  15. ^


    Mehrotra, S.; McKim, G. South. (2006). “Temporal Analysis of Meiotic DNA Double-Strand Intermission Formation and Repair in Drosophila Females”.
    PLOS Genetics.
    2
    (11): e200. doi:10.1371/journal.pgen.0020200. PMC1657055. PMID 17166055.


  16. ^


    a




    b




    Lenormand T (February 2003). “The evolution of sex dimorphism in recombination”.
    Genetics.
    163
    (two): 811–22. doi:10.1093/genetics/163.2.811. PMC1462442. PMID 12618416.


  17. ^


    a




    b




    Barr JN, Fearns R (June 2010). “How RNA viruses maintain their genome integrity”.
    The Journal of Full general Virology.
    91
    (Pt half dozen): 1373–87. doi:10.1099/vir.0.020818-0. PMID 20335491.



  18. ^


    Simon-Loriere, Etienne; Holmes, Edward C. (August 2011). “Why do RNA viruses recombine?”.
    Nature Reviews Microbiology.
    9
    (8): 617–626. doi:10.1038/nrmicro2614. ISSN 1740-1526. PMC3324781. PMID 21725337.



  19. ^


    Rawson JM, Nikolaitchik OA, Keele BF, Pathak VK, Hu WS (Nov 2018). “Recombination is required for efficient HIV-1 replication and the maintenance of viral genome integrity”.
    Nucleic Acids Research.
    46
    (20): 10535–10545. doi:10.1093/nar/gky910. PMC6237782. PMID 30307534.



  20. ^


    Muslin C, Mac Kain A, Bessaud M, Blondel B, Delpeyroux F (September 2019). “Recombination in Enteroviruses, a Multi-Stride Modular Evolutionary Process”.
    Viruses.
    xi
    (nine): 859. doi:10.3390/v11090859. PMC6784155. PMID 31540135.



  21. ^


    Hu WS, Temin HM (November 1990). “Retroviral recombination and reverse transcription”.
    Science.
    250
    (4985): 1227–33. Bibcode:1990Sci…250.1227H. doi:10.1126/scientific discipline.1700865. PMID 1700865.


  22. ^


    a




    b




    Bernstein H, Bernstein C, Michod RE (January 2018). “Sex activity in microbial pathogens”.
    Infection, Genetics and Evolution.
    57: eight–25. doi:ten.1016/j.meegid.2017.10.024. PMID 29111273.


  23. ^


    a




    b




    c




    Su Due south, Wong G, Shi Westward, Liu J, Lai AC, Zhou J, Liu W, Bi Y, Gao GF (June 2016). “Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses”.
    Trends in Microbiology.
    24
    (6): 490–502. doi:10.1016/j.tim.2016.03.003. PMC7125511. PMID 27012512.


  24. ^


    a




    b




    Nikolaidis, Marios; Markoulatos, Panayotis; Van de Peer, Yves; Oliver, Stephen Grand; Amoutzias, Grigorios D (2021-ten-12). Hepp, Crystal (ed.). “The neighborhood of the Spike gene is a hotspot for modular intertypic homologous and non-homologous recombination in Coronavirus genomes”.
    Molecular Biology and Evolution.
    39: msab292. doi:ten.1093/molbev/msab292. ISSN 0737-4038. PMC8549283. PMID 34638137.



  25. ^


    Bernstein H (1962). “On the mechanism of intragenic recombination. I. The rII region of bacteriophage T4”.
    Journal of Theoretical Biology.
    3
    (3): 335–353. Bibcode:1962JThBi…3..335B. doi:10.1016/S0022-5193(62)80030-7.



  26. ^


    Graham, Rachel Fifty.; Deming, Damon J.; Deming, Meagan Due east.; Yount, Boyd L.; Baric, Ralph Due south. (December 2018). “Evaluation of a recombination-resistant coronavirus as a broadly applicable, rapidly implementable vaccine platform”.
    Communications Biology.
    1
    (ane): 179. doi:ten.1038/s42003-018-0175-vii. ISSN 2399-3642. PMC6206136. PMID 30393776.



  27. ^


    Kirkegaard K, Baltimore D (November 1986). “The mechanism of RNA recombination in poliovirus”.
    Cell.
    47
    (3): 433–43. doi:x.1016/0092-8674(86)90600-8. PMC7133339. PMID 3021340.



  28. ^


    Cheng CP, Nagy PD (November 2003). “Mechanism of RNA recombination in carmo- and tombusviruses: testify for template switching by the RNA-dependent RNA polymerase in vitro”.
    Journal of Virology.
    77
    (22): 12033–47. doi:ten.1128/jvi.77.22.12033-12047.2003. PMC254248. PMID 14581540.



  29. ^


    Wang H, Pipes L, Nielsen R (2020-ten-12). “Synonymous mutations and the molecular evolution of SARS-Cov-2 origins”. bioRxivten.1101/2020.04.20.052019.


  30. ^


    Li X, Giorgi EE, Marichannegowda MH, Foley B, Xiao C, Kong XP, Chen Y, Gnanakaran S, Korber B, Gao F (July 2020). “Emergence of SARS-CoV-two through recombination and strong purifying selection”.
    Science Advances.
    half-dozen
    (27): eabb9153. Bibcode:2020SciA….6.9153L. doi:10.1126/sciadv.abb9153. PMC7458444. PMID 32937441.



  31. ^


    Boni MF, Lemey P, Jiang X, Lam TT, Perry BW, Castoe TA, et al. (November 2020). “Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic”.
    Nature Microbiology.
    5
    (11): 1408–1417. doi:10.1038/s41564-020-0771-four. PMID 32724171.



  32. ^


    Neches RY, McGee MD, Kyrpides NC (November 2020). “Recombination should non be an reconsideration”.
    Nature Reviews. Microbiology.
    18
    (eleven): 606. doi:ten.1038/s41579-020-00451-1. PMC7503439. PMID 32958891.



  33. ^

    Nowak MA, Ohtsuki H. Prevolutionary dynamics and the origin of evolution. Proc Natl Acad Sci U South A. 2008 Sep 30;105(39):14924-7. doi: 10.1073/pnas.0806714105. Epub 2008 Sep 12. PMID 18791073; PMCID: PMC2567469

  34. ^

    Lehman N. A case for the extreme artifact of recombination. J Mol Evol. 2003 Jun;56(half-dozen):770-vii. doi: x.1007/s00239-003-2454-1. PMID 12911039

  35. ^

    Smail BA, Clifton BE, Mizuuchi R, Lehman Northward. Spontaneous advent of genetic diverseness in RNA populations through multiple recombination mechanisms. RNA. 2019 Apr;25(4):453-464. doi: 10.1261/rna.068908.118. Epub 2019 Jan 22. PMID 30670484; PMCID: PMC6426292
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External links

[edit]

  • Animations – homologous recombination: Animations showing several models of homologous recombination
  • The Holliday Model of Genetic Recombination
  • Genetic+recombination at the US National Library of Medicine Medical Subject Headings (MeSH)
  • Animated guide to homologous recombination.

Public Domain This article incorporates public domain material from the NCBI document:
“Scientific discipline Primer”.



Which Process of Genetic Recombination Involves Genes From Both Parents

Source: https://en.wikipedia.org/wiki/Genetic_recombination